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While this typically resolves on its own, adequate protein intake, hydration, and consistent sleep schedules help patients better manage this period

Another LRRK2 inhibitor NEU-411 is currently investigated in a phase 2 trial (NEULARK, NCT06680830, see Table 5) 5.3 Targeting -Synuclein Pathology Based on the robust evidence for a central role of intraneuronal misfolding, oligomerization and aggregation of -synuclein as well as cell-to-cell transmission of pathological -synuclein species these mechanisms have become key targets for drug development programmes focused on disease modification in PD

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