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Chemico-Biol Interact 231:98107 Natarajan K, Abraham P, Kota R, Isaac B (2018) NF-B-iNOS-COX2-TNF inflammatory signaling pathway plays an important role in methotrexate induced small intestinal injury in rats

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Importantly, when quantifying synapse numbers in the hippocampus using electron microscopy and Golgi stain methods, it was found that the 3xtg mouse model developed loss of synapses, which was prevented by DA4-JC (Figure 3 for details)