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They stimulate insulin release and inhibit glucagon release
In addition to its role in cell cycle regulation, miR-222 also targets Hmbox1, a transcription factor that activates the Transforming Growth Factor- (TGF- )/Smad signaling pathway
These include reduced gonadotropin secretion due to impaired positive estrogen feedback on luteinizing hormone (LH) secretion in women (21), increased adrenal androgen secretion (22), and direct blockade of gonadotropin action at the gonadal level (23, 24)
Additionally, the evidence base for efficacy and safety specifically in BED populations remains limited
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