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Abbreviations Pb lead ROS reactive oxygen species GSH glutathione MDA malondialdehyde Nrf2 nuclear factor erythroid 2-related factor 2 HO-1 heme oxygenase 1 ARE anti-oxidative response element SOD superoxide dismutase ER endoplasmic reticulum UPR unfolded protein response GRP78 glucose-regulated protein 78 PERK protein kinase RNA-like ER kinase CHOP C/EBP-homologous protein

Gastroenterology 158 , 18991912 (2020)