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A 2024 study (SWIFT) tested a rapid initiation protocol: one day of buprenorphine, a 24-hour opioid-free period, then gradual titration of low-dose oral naltrexone before the injection

However, greater insulin resistance may initially blunt the glucose-lowering response until weight loss and lifestyle modifications take effect

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Furthermore, an interesting study showed that l-carnitine can transactivate glucocorticoid-responsive promoters in vitro, in a way similar to dexamethasone [83], suppressing the release of TNF- and IL-2 by IFN- primed and/or LPS-stimulated human primary monocytes