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*Correspondence: Ranjeet R

baseline *500mg/day and placebo data from published RCT

Pen devices make self-injection easier and more consistent than vials and syringes

Cardiogenic control of affective behavioural state

Before considering any combination approachwhich, as discussed, is not recommended outside research settingspatients and healthcare providers should focus on optimising single-agent therapy and addressing all modifiable factors affecting weight management outcomes