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Am J Physiol Regul Integr Comp Physiol 2005

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The difference rarely comes down to the peptide itself

Changes in sleep or eating patterns

The subsequent production of inflammatory cytokines, such as IL-1, IL-6, and TNF-, by these nociceptive free endings elicit spontaneous, repetitive action potentials in sensory afferents

What happens at the molecular level When a peptide degrades, it does not simply become "weaker." The peptide chain, a specific sequence of amino acids connected by peptide bonds, physically breaks apart or chemically transforms