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To date, no studies have demonstrated superiority of SGLT2 inhibitors, GLP1-RAs, or glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonists (GIP/GLP1- RAs) over metformin as first-line therapy in people newly diagnosed with type 2 diabetes
The site pharmacist remained unblinded throughout the duration of the trial
[14, 15, 16, 17, 18, 19, 20] For detailed information on the serendipity discovery of GIP and its functional studies, please see nice review articles and other publications elsewhere, [21, 22, 23] including the In Memoriam composed by Timothy Kieffer (a formal PhD student of late professor John Brown) in 2017
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