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67 Similar results were found in a study of atherosclerotic rats, in which FGF21 was able to alleviate inflammation and oxidative stress by activating the Nrf1-ARE pathway

As opposed to GLP-1 analogues, DPP-4 inhibitor treatment increases portal vein GLP-1 concentrations, and activates the gut-to-brain vagus nerve activity [113]

Appl Biochem Microbiol 61 , 126 (2025)

and permitting flexibility with food choices and occasional portion-controlled treats rather than severe restriction

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