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M1 macrophages also contribute to airway remodeling by releasing proteases (e.g., matrix metalloproteinases) and growth factors, exacerbating airflow limitation (97)

Because KLRG1 is widely used as a marker of highly activated, cytokine-producing ILC2s (66, 67), this finding supports the idea that melatonin drives a phenotypic transition from an activated, KLRG1 high effector state toward a more quiescent, KLRG1 low phenotype

3 The rash may be painful and almost always has mucous membrane involvement