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Through downregulating monocyte chemoattractant protein-1 expression, semaglutide treatment, an FDA-approved GLP-1 RA medicine targeting Type II diabetes mellitus (T2DM) (Christou et al., 2019), inhibited monocyte migration and infiltration from the circulatory system to inflammatory regions (Pontes-da-Silva et al., 2022)

Risk and reward Experts believe the combination of all three hormones is why GLP-3 drugs could prove to be more effective going forward

The article uses berberine as its example of a popular supplement whose trial base has not caught up with its reputation

10.1016/S1472-6483(10)61170-4 140