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Schwabe M, Spiridonov S, Yanik EL, Jennings JW, Hillen T, Ponisio M, et al

This timing allows tirzepatide levels to drop significantly while maintaining some GLP-1 receptor stimulation during the transition

doi: 10.1016/j.freeradbiomed.2015.10.410

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Four weeks gives the gastrointestinal tract enough time to adapt to each level of receptor stimulation before the next increase