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Its glucose-lowering and insulinotropic efficacy was superior to that of selective GLP-1 receptor agonists in diet-induced obese and leptin receptor-deficient mice, as well as in monkeys and humans [74]

Spatial transcriptomic analysis of glutamatergic neurons in the brains of patients with depression has shown that their distribution in the deep medial prefrontal cortex is tightly connected to the pathogenesis of the disorder [376]