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Mild symptoms may improve as the body adjusts or after the injection site is changed

The deviation from linearity is probably due to geometric constraints in the roGFP barrel similar to those described for roGFP1-iR which had been expected to be less reducing than roGFP1-iL due to stabilization of the thiolate anion by the introduced adjacent basic arginine residue (Lohman and Remington, For live cell measurements biosensors should ideally exhibit a strong preference for one specific analyte

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pmid:28139198 12

In the systematic review by Lauti et al

Pop-Busui, R., Lu, J., Lopes, N