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c , UMAP of sequenced DRG cells showing intermingled distribution of cells from control, EndoS treated autoantibodies and autoantibodies (Arthritis) combined with in vivo IFN block (IFNAR1 antibody)

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Within the central nervous system, B12 is vital for maintaining the myelin sheath that protects nerve fibres and for methylation processes that support neurological function, indirectly affecting neurotransmitters involved in mood regulation