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A.AlvauA.EscoffierJ.KrapfD.Snchez-CrdenasC.et al (2015)

Pyruvate kinase (encoding by pykF ) catalyzes phosphoenolpyruvic acid (PEP) to form pyruvate and is a rate-limiting enzyme in the glycolysis pathway

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Remarkably, the heterologous expression of an engineered bifunctional bacterial GSH biosynthetic enzyme ( GshF ) in mitochondria enabled mitochondrial GSH production and ameliorated the metabolic and proliferative defects caused by its depletion

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