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Published studies are mostly small case reports rather than randomized trials

Although well-designed clinical trials are required to ascertain the risk/benefit of plant-based diets, emerging evidence has questioned the practices of severely limiting potassium intake from fruits and vegetables over the years to reduce the risk of and treatment of hyperkalemia [23]

GLP-1 helps people feel full and lowers glucose, GIP supports fat and nutrient handling, and glucagon pushes the body to burn energy

Hypothalamic mTOR signaling regulates food intake

There might also be opportunities for GLP-1 drugs to be modified somehow to circumvent the impacts of these PAM gene variations but it's still early days in that regard

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