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10.1007/978-3-642-00663-0_12 37 HiramitsuM.ShimadaY.KuroyanagiJ.InoueT.KatagiriT.ZangL.et al (2014)

When functioning properly, this sphincter opens to allow food passage into the stomach, then closes tightly to prevent acidic contents from traveling upward

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This means peptides should not be viewed as replacements for proven treatments

Protein-tyrosine nitration is a post-translational chemical modification process for the highly selective non-enzymatic introduction of a nitro group (-NO 2 ) into the side chain by peroxynitrite (ONOO - ), a short-lived biomolecule generated by the rapid reaction of NO with superoxide radicals in vivo 40,41