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Upon receiving the shipment, place the product in a refrigerator immediately (28 C)

Naltrexone/bupropion (Contrave): Naltrexone works as an opioid receptor antagonist, which can reduce the rewarding effects of food and cravings, particularly for high-calorie, high-sugar foods

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The most common side effects of both are gastrointestinal: nausea, diarrhoea, vomiting, and constipation

As expected, treatment with DEM, started at 72 hours after knock-down initiation, leads to a significantly reduced response compared to siCtrl (Fig 3A)