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KEY TAKEAWAY: Month 3 is the turning point

This blockade inhibits the downstream Smad2/3 pathwaywhich otherwise promotes muscle protein degradation and atrophyand instead promotes muscle hypertrophy and differentiation [175]

Moreover, in mice we observed that chronic l-carnitine supplementation resulted in markedly elevated plasma BB levels (more so than l-carnitine or TMAO), and it was the first step of the overall gut microbial catabolic pathway (i.e., l-carnitineBB) that was induced in mice following chronic l-carnitine dietary exposure (26)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 68.Tavella S, Raffo P, Tacchetti C, Cancedda R, Castagnola P