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Journal of Cosmetic Dermatology [Internet]

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Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes

The pathophysiology of DOX-induced POI is complex, but numerous factors have been proposed to be linked to the onset and development of ovarian dysfunction, including free radical-mediated lipid peroxidation, oxidative stress, mitochondrial malfunction, increased proinflammatory release of cytokines, and granulosa cell apoptosis 12,13,14

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