Back Laughton, NB, Macallum, AB (1 June 1932) 'The Relation of duodenal mucosa to internal secretion of the pancreas', Proceedings of the Royal Society of London
N Engl J Med, 389(6), 514526
A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivity
It is not yet FDA-approved (still in Phase 3 trials as of February 2026), so it is only available through research suppliers
The low end represents bulk purchasing from competitive vendors
Retatrutide is commonly listed with the molecular formula C221H342N46O68 and an approximate molecular weight around 4731 Da depending on listed salt/form