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Prata et al., 2017)

This preservation of surface receptor density ensures that the somatotroph axis remains sensitive to subsequent hormonal spikes, thereby preventing the "plateau effect" observed with lower-selectivity secretagogues

These medications are also being targeted by Kennedys commission

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In real-world settings, about 65% of people who discontinued a GLP-1 medication (semaglutide or liraglutide in this case) gained weight after stopping treatment