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doi: 10.1098/rsob.200200 190 KimD-GJungKHLeeD-GYoonJ-HChoiKSKwonSWet al

Multiple assays were performed to assess cellular status and molecular changes

Risks of Improper IGF-1 LR3 Dosing Because IGF-1 stimulates growth pathways, excessive or unsupervised dosing may increase risks, including: Hypoglycemia (low blood sugar) Edema Joint discomfort Nerve compression symptoms Potential overstimulation of mitogenic pathways IGF-1 signaling is also involved in cellular proliferation

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Gene delivery In vitro and in vivo studies have proven the efficacy of IGF-1 gene therapy in OA treatment [16, 60, 61]