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Furthermore, a 2024 bidirectional Mendelian randomization study confirmed the causal relationship between depression and chronic constipation genetically (OR = 11.43, 95% CI: 1.8570.67, P = 0.008), while the reverse analysis did not identify a significant causal effect of constipation on depression, suggesting that depression may be an upstream factor in the development of chronic constipation ( The emergence of the microbiota-gut-brain axis (MGBA) theory in exploration of the pathophysiological mechanisms underlying the comorbidity of chronic constipation and depression has provided novel perspectives for understanding this complex phenomenon