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This includes excess sugar, processed carbohydrates, and industrial seed oils Excess carbs and sugars cause blood sugar to spike, then fall rapidly and this upsets the nervous system by spiking cortisol levels because adrenals are put in a position to release extra cortisol to bring back blood glucose balance

Here we compare the published data from the STEP-1, SURMOUNT-1, and TRIUMPH-4 trials without marketing spin: -14,9% for semaglutide, -20,9% for the tirzepatide-28,7% for the retatrutideThe retatrutide vs tirzepatide vs semaglutide comparison also incorporates tolerance (dysesthesia 20,9% at the 12 mg dose level of retatrutide), pleiotropic effects 2024-2025 (apnea, heart failure, MASLD), and the updated regulatory status in France 2026

This protective effect was evident upon cessation of XPP treatment [64]

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