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The replacement of the carboxyl group with a neutral amide effectively reduced the impact of matrix acidbase chemistry on sensitive compounds, thereby enhancing the analytical reliability

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In this study, we expand the application of PNP hydrogels Sema depots [38] to formulate long- acting TZP depots, engineered for months-long, steady-state release following a single injection ( Figure 1C E ), and compare their therapeutics effects and pharmacokinetics release profile

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