Meaningful structural improvements in bone continuity and strength have been observed between weeks four and eight in animal models
It has no approved indication, no standardized dosing, and no manufacturer-backed clinical data
semaglutide in direct comparison The clearest head-to-head trial between the two approved molecules for obesity is SURMOUNT-5 (Aronne et al., NEJM 2024, NEJMoa2416394)
Blood 94:207b, 1999
Herein, the mechanism of probiotics influencing bone health involves first exerting in situ effects on the gut microbiota and intestinal barrier, then affecting the interactive pathways of the gutbone axis (including endocrine, inflammation, and immunity), and ultimately regulating bone homeostasis
(PubMed) Food and Nutrition Board, Institute of Medicine