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Thoughtful individualization based on patient characteristics, systematic titration allowing tolerance development, and systematic monitoring enables development of personalized protocols delivering optimal outcomes within each individual's physiologic capacity and treatment goals

Some people find that sparkling water, herbal teas, or diluted electrolyte drinks are more tolerable than still water during periods of significant nausea

Br J Pharmacol 105:10091013 Jackson RA, Hawa MI, Jaspan JB et al (1987) Mechanism of metformin action in non-insulin-dependent diabetes

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Plasma iron concentrations are maintained at a low level (as complexes with transferrin), and this decreases substantially during the acute phase response to infection or other inflammatory stimuli (Ganz, 2018