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Therefore, in states of chronic under-nutrition, hepatic GH resistance is an adaptive response, as high GH levels are necessary to maintain euglycemia, while low IGF-I levels conserves energy during periods of nutritional deprivation

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doi: 10.3389/fimmu.2024.1302587 179 ZhengRLiuXZhangYLiuYWangYGuoSet al