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Whether semaglutide has the same platelet effect at equivalent receptor activation levels remains unconfirmed, though the shared mechanism of action makes it plausible

The culture medium was exchanged by an extracellular solution containing (in mM) 140 NaCl, 2.5 KC1, 1 MgCl 2 , 3 CaCl 2 , 25 glucose, and 5 HEPES

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The SURMOUNT-1 trial found that participants on tirzepatide 15mg achieved an average weight loss of 20.9% of body weight, while the STEP 1 trial found semaglutide 2.4mg produced an average of 14.9%

These findings support biological delivery, but they do not establish that one form produces better clinical outcomes