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A randomized, double-blind, placebo-controlled trial in 191 older adults (75 years) with moderate vitamin B 12 deficiency (serum cobalamin concentrations of 107-210 pmol/L) without anemia provided participants with 1 mg/day of cyanocobalamin for one year (94)

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Conversely, chronic NAD+ depletion during aging can impair both PARP-mediated DNA repair and sirtuin-mediated stress resistance, contributing to accelerated aging phenotypes