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Expression of interferon-stimulated genes in insulitic pancreatic islets of patients recently diagnosed with type 1 diabetes

For patients who have difficulty absorbing B12 through the digestive tractsuch as those with pernicious anemia, gastrointestinal disorders (like Crohns disease or celiac disease), a history of gastric bypass surgery, or those with severe B12 deficiencyour providers often recommend intramuscular B12 injections

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This stability underpins the entire rationale for oral dosing: a molecule that survives the stomach can plausibly exert effects directly on the gastrointestinal mucosa, and potentially be absorbed in functional form

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