Figure 3 5 Strategies for osteoporosis management: gutbone axis targeted 5.1 FMT, probiotics, and prebiotics 5.1.1 FMT As a novel technique of organ transplantation, FMT involves transferring fecal microbiota from healthy donors to recipients to modify disturbed intestinal ecology, whose efficacy in treating digestive diseases such as Clostridioides difficile infection (CDI) (119), ulcerative colitis (120), and IBS (121) has been repeatedly verified
PI3K-AKT-mTOR Pathway The PI3K-AKT-mTOR pathway is another frequently activated oncogenic signaling cascade in MM, which is verified by elevated AKT phosphorylation through immunohistochemical staining (102, 103)
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The entire process takes under five minutes
Dorsch et al., 2011