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Furthermore, stabilization of NRF2 in cancer cells harboring oncogenic RAS induces genes encoding stress-responsive enzymes, including GPXs, NAD(P)H:quinone oxidoreductase-1 (NQO1), glutamate-cysteine ligase (GCL), GR, heme oxygenase-1 (HO-1), and glutathione S-transferase (GST), some of which are directly involved in cellular glutathione biosynthesis and ROS detoxification 22,23,24

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In an acute sense, electrolyte imbalances can result in muscle issues, neurological problems, digestive upset, and even heart rhythm changes 35

Yoo S-E, Chen L, Na R, Liu Y, Rios C, Van Remmen H et al (2012) Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain