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Structurally, semaglutide is an acylated peptide analogue of native GLP-1

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Regarding basal cortisol, children with PWS are generally able to produce adequate levels in daily life, as demonstrated by studies showing normal average morning basal serum cortisol (6466) or salivary cortisol (51)

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Beyond its insulinotropic effects, GLP-1 has beneficial physiological activities in the brain [13], heart [14], and lung [15], sustained notably by strong anti-inflammatory activities [10,16]