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Even when insulin is used, these classes of medications still provide benefits. Joanna Khatib In a meta-analysis, Khatib and colleagues assessed major adverse CV events from eight recent CV outcome trials for SGLT2 inhibitors, GLP-1 receptor agonists and DPP-IV inhibitors: DECLARE, EMPA-REG, EXSCEL, HARMONY, LEADER, SUSTAIN-6, EXAMINE and SAVOR-TIMI 53

Additionally, aspiration risk has been raised as a concern primarily in perioperative settings due to delayed gastric emptying, leading to recent multi-society anesthesia guidelines addressing GLP-1 receptor agonist management before procedures

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