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Department of Health and Human Services, 2025, www.nia.nih.gov/health/menopause/what-menopause.
Average Weight Loss on Semaglutide In the main clinical trial that supported semaglutide's approval for weight management (the STEP 1 trial), adults who took the 2.4 mg weekly dose lost, on average, about 15% of their body weight over 68 weeks, compared with a much smaller amount in the placebo group
Patients can expect an average weight loss of about 15-16% with semaglutide over a year, which is substantial compared to other weight loss medications, she says
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If you are taking a prescription weight loss medication such as semaglutide or orlistat through an NHS or private pathway, your prescribing clinician should be informed of any new or unusual symptoms
