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Increased fatigue

Research into this area is still developing, but several studies have shown reductions in C-reactive protein (CRP) and other inflammatory markers in patients on GLP-1 therapy that exceed what would be expected from their degree of weight loss alone

These drugs, GLP-1 receptor agonists, were originally designed to harness the same pathways that naturally produce GLP-1

Sokos GG, Nikolaidis LA, Mankad S, Elahi D, Shannon RP: Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure

There were 12 serious adverse events recorded across the trial, including one suspected unexpected serious adverse reaction related to restrictive eating behaviour in a participant receiving semaglutide