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Moreover, intrauterine devices (IUD) releasing levonorgestrel are a very suitable option for cases with adenomyosis and increased risk for thrombotic conditions for whom systemic therapy could not be advisable [61, 62] (e.g., women above 40 years old, increased BMI, increased risk for estrogen-dependent diseases such as breast cancer or endometrial hyperplasia)

To address the functional role of HSL in vivo, several laboratories generated HSL-null mouse models (44, 94, 134)

Lean mass dropped by 9.7% , while fat mass fell by 19.3%