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Urocortins and CRF type 2 receptor isoforms expression in the rat stomach are regulated by endotoxin: role in the modulation of delayed gastric emptying

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They concluded that the risk-edited cells increased a T cell activation profile following non-specific TCR engagement, which mimicked the observations exhibited by PTPN22 knockout cells, suggesting the risk variant acts as a loss-of-function mutant that reduces the ability of LYP to inhibit TCR activation (74)

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