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516 In the primary cell (sPD cell) derived from patients with sporadic PD, the cytosolic conversion of pyruvate to lactic acid resulted in a significant increase in the nuclear NAD + level and cellular NAD + /NADH ratio

C.Snchez-CalvoB.ChakiM.Mata-PrezC.ValderramaR.PadillaM

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Sci Rep 6:117

Given the fact that APAP toxicity is initiated by metabolism through cytochrome P450 enzymes, any subtle interference with the formation of reactive metabolite NAPQI and accumulation of APAP protein adducts (APAP-ADs) can produce a profound impact on the outcome of APAP-induced liver injury

Andreazza AC, Kauer-Santanna M, Frey BN, Bond DJ, Kapczinski F, Young LT, Yatham LN (2008) Oxidative stress markers in bipolar disorder: a meta-analysis