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Chronic inflammation increases the risk of colorectal cancer, necessitating regular surveillance colonoscopy, typically beginning 8 years after disease onset for extensive colitis, with intervals of 1-3 years based on individual risk factors

Thats because theres not enough research on the efficacy or safety of combining them

The relevant study also found that the 1-year average weight loss of participants (LIR 3.0 mg) was 9.2 kg reporting nausea/vomiting episodes, while that of participants without nausea/vomiting was 6.3 kg

Nature (2017) 543:38590

But theres more to understanding whats going on with estrogen than the ratio of estrogen to progesterone

Chen Y, Jacamo R, Konopleva M, Garzon R, Croce C, Andreeff