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Absolute contraindications include: Personal or family history of medullary thyroid carcinoma : These medications carry a boxed warning regarding thyroid C-cell tumors based on rodent studies Multiple endocrine neoplasia syndrome type 2 (MEN 2) : Increased risk of medullary thyroid carcinoma Previous serious hypersensitivity reaction : To semaglutide, tirzepatide, or any formulation component Pregnancy considerations: These medications are not recommended during weight management in pregnancy due to limited safety data and potential fetal risks

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For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles

Tirzepatide (Mounjaro, Zepbound) works through a related but distinct mechanism as a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist

b , Cdkn1a , Ccl2 and Ccl5 mRNA levels in ID8 Trp53 / omental tumours