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When administered together, their mechanisms converge to amplify appetite regulation, energy intake reduction, and glycemic improvements, exceeding the individual effects of monotherapy by acting on complementary neuroendocrine circuits regulating body weight and metabolism 1-3

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3.6.2 Gutbrain axis alterations in stroke Growing evidence reveals that stroke not only disrupts CNS homeostasis but also profoundly alters the MGBA, leading to bidirectional interactions that can exacerbate neuroinflammation and hinder recovery