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doi: 10.1152/ajpgi.00248.2006 116 KiskovTKassayovM

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By upregulating the mitochondrial anti-apoptotic pathway through an increase in AMP-activated protein kinase (AMPK) phosphorylation and an increase in the Bcl-2/Bax ratio (AMPK), modest dosages of withaferin A were found to have a cardioprotective effect in this rat investigation [54]

Here is how to reduce side effects- Start with a low concentration of glycolic 5-10%