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The two are often discussed together because both sit within the broader GLP-1 research and metabolic signalling conversation, but they are not the same type of product and should not be treated as interchangeable

This is why they are used in obesity management and diabetes care

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Retatrutide titration protocol Retatrutide follows a similar monthly escalation pattern, but with different starting points and targets: Weeks 1-4: 1mg once weekly (initiation) Weeks 5-8: 2mg once weekly Weeks 9-12: 4mg once weekly Weeks 13-16: 8mg once weekly Week 17+: 12mg once weekly (maintenance) The retatrutide starting dose is lower at 1mg, reflecting the triple agonist mechanism and the need for careful GI adjustment

A higher percentage of semaglutide users achieved greater weight loss