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Low energy frequently stems from poor mitochondrial function and cellular oxidative stress

16th Annual John Goldman Conference on Chronic Myeloid Leukemia: Biology and Therapy, 2014

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We propose that chronic exposure to a particular suite of environmental and genetic factors elicits a trajectory of impaired mitochondrial biology that maximally impacts subsets of mitotypes abundant in the hippocampus, entorhinal cortex, and cerebral cortex, which eventually surfaces as the hallmark features of AD