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Retatrutide has balanced agonism at all three receptors, distinguishing it from tirzepatide (dual GIP/GLP-1) and semaglutide (selective GLP-1)

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10.1038/s41422-020-0384-8 51 MaJ.ShiM.ZhangX.LiuX.ChenJ.ZhangR.et al (2018)

This mechanism contributes to their weight loss benefits

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