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Wu GD, Chen J, Hoffmann C, Bittinger K, Chen Y-Y, Keilbaugh SA, et al

The term GLP-1 supplements encompasses a wide range of productsfrom oral peptide mimetics to compounded injectable formulationswith varying clinical evidence and regulatory pathways

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206,220,221 Given that endoplasmic reticulum stress, impaired autophagy and proliferation, and increased apoptosis are all suggested to promote islet beta-cell pathology in T2D, and the findings that GLP-1R activation can influence all of these give GLP-1 and its analogues a role beyond just enhancing insulin secretion

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Pitta , associated with enzymatic and metabolic activities, is particularly significant in digestion